Abstract
A procedure is described by which individual capsules or tablets of aspirin containing medicinals can be conveniently and accurately assayed for salicylic acid. Each unit, including the capsule or any tablet coating, is extracted with alcohol and subsequently diluted with water. The salicylic acid absorbance at 300 mμ is measured employing an appropriate aspirin containing reference solution. Results obtained with known amounts of added salicylic acid give satisfactory reproducibility; average discrepancy from known content of salicylic acid is 0.4 per cent. While the procedure is designed principally for following appearance of free salicylic acid, as aspirin containing medicinals age or deteriorate, it is applicable down to allowable limits in marketed aspirin and APC products.
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