Abstract
<h3>Aims</h3> Many studies revealed that patients with diabetes (DM) had higher risk in developing atherosclerosis and its complicated clincal outcome. Aspirin, a widely prescribed antiplatelet drug, was beneficial in the primary and secondary of cardiovascular diseases. However, its efficacy varies. The aim of our studywas to determine if there is a correlation betweenAspirin Resistance (AR) and clinical outcomes in patients with DM and coronary artery disease (CAD). <h3>Methods</h3> 108 aged CAD patients were enrolled in this study,among who 27 were with DM, and 81 were without DM. Aspirin response was assessed by urinary11-DehydrothromboxaneB2 (11dhTxB2) measurement before and after 100 mg/d aspirin administration. Aspirin resistance (AR) was defined as urinary11dhTxB2 >1500 pg/mg. The measured clinical outcomes were defined as the occurrence of cardiovascular events and death. <h3>Results</h3> The mean baseline urinary 11dhTxB2 of CADpatients was 3463 ± 2465 pg/mg. In subgroup analysis, patients withDM (3887 ± 1857 pg/mg) had higher baseline urinary 11dhTxB2 than CAD patients (3210 ± 934 pg/mg) (p < 0.001). After aspirin administration, the urinary 11dhTxB2 of CAD patients with and without DM were significantly lower than their baseline value (856 ± 748 pg/mg, 1054 ± 859 pg/mg, P < 0.001). The prevalence of AR in CAD patients with or without DM were 18.3% and 6.4% according to the defined criterion Urinary11dhTxB2 >1500 pg/mg. Within a mean follow-up time of 12 months, the outcomesoccurred more frequently in AR patients withDM than AR patients without DM (p < 0.05). <h3>Conclusion</h3> The baseline and after administration urinary 11dhTxB2 levels in CAD patients with DM were significantly higher than CAD patients without DM. Incidence of 1-year clinical outcome in CAD patients with DM was significantly higher than those without DM. Further studies are needed to confirm our results.
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