ASSA13-14-21 The Effects of Fosinopril on the Level of Serum Adiponectin and the Expression of Adiponectin and the Expression of Aortic Adiponectin Receptor 1 in Spontaneously Hypertensive Rats

Abstract

<h3>Objective</h3> To observe adiponectin receptor-1 expression in vascular walls of spontaneously hypertensive rats (SHR) and the effect of fosinopril on it. <h3>Methods</h3> Fourteen weeks old male SHR were randomly divided into three groups: SHR group, fosinopril 10 mg group and fosinopril 20 mg group; 14-week old male Wistar-kyoto rats (WKY) were regarded as the control group. After 8 weeks, blood pressure, serum adiponectin was detected; the ratio of media/lumen radius was detected by using hematoxylin-eosin, the expression of adiponectin receptor 1 on the vascular walls were tested by immunohistochemistry. <h3>Results</h3> As compared to SHR group, the ratio of wallthickness to lumen radio, the serum levels of adiponectin with total fosinopril were increased (P &lt; 0.05), and the expression of adiponectin receptor 1 was significantly increased (P &lt; 0.05). <h3>Conclusions</h3> Fosinopril can reduce the levels of blood pressure, increase the levels of serum adiponectin and the expressioin of adiponecin receptor-1 on the aorta in hypertension rats.