Abstract
<h3>Objective</h3> To investigate the impossible association between C-reactive protein (CRP) gene T-757C polymorphism in the promoter region and unstable angina pectoris (UAP) in a Chinese Han population of Suwan region. <h3>Methods</h3> This study was conducted with a case-control design including 165 patients with UAP (UAP group) and 282 control subjects who were free from coronary artery disease through coherence checks (control group). The T-757C polymorphism in CRP gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. <h3>Results</h3> Compared with the control group, the frequencies of TT, TC and CC genotype were not significantly different in UAP group (P > 0.05). The prevalence of T allele was 77.6% and 79.1% (P > 0.05), respectively in the UAP group and control group. Multivariate logistic regression analysis indicates that there was no significant correlation between CRP gene T-757C polymorphism and UAP (P > 0.05). <h3>Conclusions</h3> Our findings suggest that the T-757C polymorphism in CRP gene may be not the risk for UAP among the Chinese Han population of Suwan region.
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