ASSA13-11-5 Relationship Between Levels of Microalbuminuria and Vascular Endothelial Function in Patients with Coronary Atherosclerotic Disease

Abstract

<h3>Objective</h3> To investigate the relationship among the levels of microalbuminuria and high-sensitivity C-reactive protein (hs-CRP) in patients with coronary atherosclerotic disease, and the role of microalbuminuria in predicting the vascular endothelial function. <h3>Methods</h3> Patients were divided into two groups according to the clinic presentation, one with stable angina pectoris (SAP group, n = 66) and the other with unstable angina pectoris (UAP group, n = 84). Mcroalbuminuria and hs-CRP levels were measured, and the endothelial function was measured by detecting the brachial artery flow-mediated asodilation (FMD), endothelins (ET), and nitric oxide (NO) as well. <h3>Results</h3> There were significant differences between SAP groups and UAP group in terms of urinary albumin-to-creatintine ratio (ACR) (0.47 ± 0.24 mg/mmol vs 0.71 ± 0.38mg/mmol, P &lt; 0.01), hs-CRP (0.49 ± 0.31mg/l vs 3.57 ± 2.15mg/l, P &lt; 0.01), NO (57.46 ± 4.07μmol/l vs 44.54 ± 5.15μmol/l, P &lt; 0.05) and FMD (5.96 ± 0.79% 3.30 ± 1.20%, P &lt; 0.05). Using the method of stepwise multiple linear regression and correlation, at the levels of α = 0.10, ACR was related to Lnhs-CRP and NO. The constant of the model is 3.570, unstandardized partial coefficient for Lnhs-CRP is 0.333 (95% CI: 0.138 ∼ 0.527, P = 0.006), NO - 0.320 (95% CI: -1.041 ∼ -0.102, P = 0.032), respectively. <h3>Conclusions</h3> microalbuminuria may act as one of the markers to evaluate the vascular endothelial function in the patients with coronary artery disease.