Abstract
Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared for targeted breast cancer therapy. The vehicle hinges on MNP altered with polymer polyethylene glycol (PG), polydopamine (PD), and F. The delivery vehicle was studied for in vitro drug release, cytotoxicity, and breast cancer cell proliferation. F-conjugated drug delivery vehicles let MNPs achieve an elevated targeting efficacy, ideal for cancer therapy. It was also observed that compared to free aspirin, our drug delivery system (MNP-Asp-PD-PG-F) has a higher cytotoxic and antiproliferative effect on breast cancer cells. The drug delivery system can be proposed as a targeted breast cancer therapy that could be further focused on other targeted cancer therapies. Delivering aspirin by the PD-PG-F system on the tumor sites promises a therapeutic potential for breast cancer treatment.
Highlights
Cancer remains one of the most serious health concerns for human beings and usually requires chemotherapy as a conventional treatment
This study aims to prepare the mesoporous silica nanoparticles (MNPs) based on aspirin in FAconjugated polydopamine (MNP-Asp-PD-polyethylene glycol (PG)-F) delivery vehicle for targeted cancer therapy, for breast cancer treatment
This study shows that MNP-Asp-PD-PG and MNPAsp-PD-PG-F could block breast cancer cell proliferation using the anticancer properties of aspirin
Summary
Cancer remains one of the most serious health concerns for human beings and usually requires chemotherapy as a conventional treatment. Breast cancer ranks as the most common cancer in women with over 1 million diagnosed cases annually (Wang et al, 2014). Aspirin Repurposing to Target Cancer resection, or radiotherapy have increased its survival rate. For example, bacillus Calmette–Guérin (BCG), induce CTL-attracting chemokines and suppressive factors and may require some changes in the therapy (Ibrahim et al, 2021)
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