Abstract
Upper respiratory tract infections or common colds are a multi-symptom disease which is usually symptomatically treated with fixed dose multi-active ingredient medicinal products which are commonly used as non-prescription and over the counter. However, the active ingredients combined require a particular and clinically sound justification. Analgesics and decongestant can be combined to treat simultaneously the prominent symptoms cold-related pain (e.g. headache, muscle aches and pains), fever, inflammationand nasal/sinus congestion. This overview provides a summary of the evidence supporting the combination of acetylsalicylic acid (aspirin) and pseudoephedrine available in the common cold product Aspirin® Complex.
Highlights
Upper respiratory tract infections or common colds are a multi-symptom disease which is usually symptomatically treated with fixed dose multi-active ingredient medicinal products which are commonly used as non-prescription and over the counter
Acute upper respiratory tract infections (URTI) which are commonly known as common cold and flu are one of the most common diseases of humans with adults suffering from 2 - 5 symptomatic infections each year and school-children from 7 - 10 each year [1]
This review presents in vitro dissolution data and clinical evidence of pharmacokinetics, efficacy and safety of this medicinal product and a justification of this multi-ingredient combination product for the symptomatic treatment of common cold and flu
Summary
Acute upper respiratory tract infections (URTI) which are commonly known as common cold and flu are one of the most common diseases of humans with adults suffering from 2 - 5 symptomatic infections each year and school-children from 7 - 10 each year [1]. The symptoms of URTI’s are so common that self-diagnosis is normal amongst the general public [3] and symptomatic self-treatments with nonprescription medicines are the most common. Common cold and flu are multi-symptom illnesses which justify the use of multi-ingredient combination products [4]. The rationale for the fixed combination products for common cold and flu is practicable, logical and reasonable when some requirements are fulfilled [5]. The constellation of symptoms makes the common cold and flu unique among common diseases as no other condition has such a range of symptoms that occur simultaneously. The possibility of interactions between the active pharmaceutical ingredients of the fixed combination needs to be considered and the release of the active substances for the symptomatic treatment of common cold and flu has to be adjusted to the presence of the symptoms
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