Abstract
Aspirin was fed to rats (2.4 g/kg of diet) in a diet deficient in copper because of an hypothesis linking the etiology of ischemic heart disease to copper metabolism and because of the apparently protective effect of aspirin in this disease. Cholesterol was measured by fluorometry and copper was measured by atomic absorption spectrometry. Aspirin decreased cholesterol in plasma approximately 18% (p<0.003) in each of two experiments. Copper in liver microsomes was doubled by aspirin (p<0.002). The effects of aspirin were compared to those of clofibrate in a similar experiment (Drug-Nutrient Interactions 2:131, 1983) and to other chemicals that alter both cholesterol metabolism and copper metabolism. Effects on copper may be central to the action of cholesterotropic agents.
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