Aspirin Formulation and Absorption Rate II: Influence on Serum Levels of Tablets, Antacids, and Solutions

Abstract

Serum salicylate levels were measured for seven aspirin preparations alone and with a mixture of dihydroxyaluminum glycinate and magnesium carbonate. A twofold increase in serum levels at 10 and 20 minutes after ingestion was observed with the mixture present. With the aspirin preparations, the salicylate serum levels clearly reflected the technology of the aspirin granulation preparation. An optimum level of antacid for rapid absorption was found. A study of the salicylate levels resulting with time from ingestion of solutions and tablets showed that more rapid absorption was accompanied by earlier and higher serum levels.