Abstract
Ling and colleagues (BJOG 2020 xxxx) have contributed important information on cardiovascular (CV) assessment over the course of pregnancy, with and without aspirin treatment, associated with risk of pre-term pre-eclampsia, as assessed by the multivariable competing risks model at 11-13 weeks. There are a number of important messages in these data. First, women at low- (vs. high-) risk of preterm pre-eclampsia appear to have lower cardiac output (CO), stroke volume (SV), and blood pressure (BP) in early pregnancy, consistent with the hypothesis that maternal CV predisposition plays a major role in pre-eclampsia risk (Ridder A et al. Int J Mol Sci. 2019;20(13)).
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