Abstract
Researchers are closer to understanding the role of aspirin and NSAIDs in preventing colorectal cancer, according to the findings from several studies presented at Digestive Disease Week [ San Diego, US; May 1995 ]. New analyses of data from the Polyp Prevention Study 1 (PPS 1) confirm that aspirin use reduces the recurrence of large bowel adenomas. However, the dosage of aspirin that may achieve this effect remains unknown. On a mechanistic note, data from in vitro studies and a study in patients with familial adenomatous polyposis (FAP) indicate that sulindac may cause adenoma regression by inducing apoptosis. In addition, the novel NSAID balsalazide, a prodrug of 5-aminosalicylic acid, has been shown to inhibit human cancer cell proliferation in vitro.
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