Abstract
The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and selected dietary factors.
Highlights
Summary The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy
At least six case-control studies (Kune et al, 1988; Rosenberg et al, 1991; Suh et al, 1993; Muscat et al, 1994; Peleg et al, 1994), based on over 3700 cases, have suggested that the risk of colorectal cancer may be reduced in regular aspirin users
Four (Thun et al, 1991, 1993; Schreinemachers and Everson, 1994; Giovannucci et al, 1994, 1995) out of five (Paganini-Hill et al, 1989; Paganini-Hill, 1994) cohort studies showed a protection of between 20% and 40% among regular aspirin users, in the American Nurses' Health Study (Giovannucci et al, 1995) the protection was only evident for frequent use (2 four times per week) and after 20 years of use
Summary
Summary The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% Cl 0.5-1.0) after allowance for education, physical exercise and selected dietary factors.
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