Abstract
Urine formation was measured in normal frogs by repeatedly weighing individuals whose cloacae were bound for a known period of time and later unbound. It was observed that in the absence of oxygen no urine formed. Even when diuresis was favored, by subcutaneous injection of water or 1% urea solution, no urine reached the bladder. When the breathing was interrupted by appropriate pithing or anesthesia the same inhibition of urine formation occurred, provided the frogs were kept at temperatures (20° to 27°C.) high enough so that oxygen was not adequately supplied to the blood through the skin. After 2 hours of asphyxia, anuria persisted for 1 to 4 hours, until such time as the frogs resumed breathing. As the frogs recovered, extra urine was formed until the initial net body weight was reestablished. The heart's circulation was maintained throughout. Two alternatives presented themselves: did (glomerular) fluid cease to form, or was the fluid that formed completely reabsorbed (by the tubules)? If no fluid fo...
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