Abstract
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM.
Highlights
Meroterpenoids are hybrid secondary metabolites that partially derive from the terpenoid pathways [1]
This endeavor resulted in the isolation of seven undescribed meroterpenoids, called as asperversins A–G (1–7), and a structurally related known compound, asperdemin (8) [20]
The Aspergillus versicolor strain was cultured on potato dextrose agar (PDA) at 28 ◦ C for 7 days to prepare the seed culture and inoculated into 100 sterilized Erlenmeyer flasks (1 L), which contained
Summary
Meroterpenoids are hybrid secondary metabolites that partially derive from the terpenoid pathways [1]. Asperterpene A, obtained from Aspergillus terreus, represents a potential lead compound and a versatile scaffold for the development of drugs for the treatment of Alzheimer’s disease [15]. Aspergillus versicolor, that were obtained from mud from the South China Sea, are reported here. This endeavor resulted in the isolation of seven undescribed meroterpenoids, called as asperversins A–G (1–7), and a structurally related known compound, asperdemin (8) [20]. 22 of elucidation, plausible biosynthetic pathway, and the biological evaluations of compounds 1–7 are ring. The isolation, structure elucidation, plausible biosynthetic pathway, and the biological presented.
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