Abstract
Publisher Summary For optimizing the industrial production of enzymes by molecular means, a logical first step is the study of the regulation of expression of the corresponding genes. The principal industrial scale fungal enzyme producers are predominantly members of the genera Aspergillus ( Aspergillus awamori , Aspergillus niger , Aspergillus oryzae ) and Trichoderma ( Trichoderma longibrachiatum , Trichoderma reesei ). Although not employed at the industrial level, Aspergillus nidulans ( A. nidulans ) is the organism of choice for carrying out such studies on gene regulation. Classical genetic studies have revealed the existence of two principal modes of genetic regulation in A. nidulans : (1) pathway-specific regulation and (2) wide-domain regulation. Pathway-specific regulation refers to the control of the synthesis of components (permeases and enzymes) of a single metabolic pathway, whereas wide domain regulation refers to control exerted over a number of different pathways. The most extensively studied examples of wide domain regulation are nitrogen metabolite repression, carbon catabolite repression, and ambient pH regulation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
