Abstract
Invasive aspergillosis mostly occurs in severely immune compromised patient and infrequently in an immunecompetent host. The usual site of infection is the pulmonary system. Extra pulmonary sites such as isolated lymphadenopathy without systemic symptoms are rare. We present a case of aspergillosis in the cervical lymph node of breast cancer patient six years after completing chemotherapy. Diagnosis was excision biopsy of an enlarged cervical lymph node and the patient was successfully treated with oral Itraconazole for three months without disease recurrence 3 years following completion of medication.
Highlights
The Aspergillus species are fungi named after a device used to disperse holy water with a similar structure to the spore
Humans are exposed to 200–2000 Aspergillus spores per day because numerous Aspergillus conidia are found to be airborne in the environment [1]
Following a highly probable diagnosis of aspergillus lymphadenitis, she was treated with oral Itraconazole 400 mg daily for three months with complete resolution of cervical lymph nodes by the end of the second week
Summary
The Aspergillus species are fungi named after a device used to disperse holy water with a similar structure to the spore. She was initially treated by wide local excision for a malignant lump in the right breast in 2005 but defaulted adjuvant treatment after 3 cycles of chemotherapy (Cyclophosphamide, Adriamycin, 5- Fluorouracil) She developed a recurrent lump in her right breast in 2006 for which she had mastectomy and axillary dissection. An excision biopsy was recommended on account of a negative metastatic workup including a normal chest X-ray, oral and chest wall and breast examination, low tumor marker levels as well a good clinical performance status. Following a highly probable diagnosis of aspergillus lymphadenitis, she was treated with oral Itraconazole 400 mg daily for three months with complete resolution of cervical lymph nodes by the end of the second week. A 63-year old female was first seen in January 2007 at the Korle-bu Teaching Hospital, Accra, Ghana following mastectomy and axillary
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