Abstract
Mangrove-associated fungi are excellent sources of bioactive natural products. To explore the value of producing bioactive secondary, the genome and transcriptome of mangrove-associated fungus named A. clavatonanicus HSF015 are sequenced for the first time. According to the genome (8737 function gene), A. clavatonanicus HSF015 with 58.05 % genes expressing shows high performance in metabolism and secondary metabolism. Forty secondary metabolite biosynthesis gene clusters are successfully annotated from 13 contigs in the genome. Thereinto, ten biosynthesis gene clusters can synthesize 17 known compounds with various activities and application values. The remaining 30 gene clusters are unknown secondary metabolite synthesis gene clusters, which are worth exploring. In addition, three known compounds with antioxidant and antibacterial activities were isolated from the broth of A. clavatonanicus HSF015. Hence, A. clavatonanicus HSF015 with the great talent in producing bioactive secondary metabolites is worth further study.
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