Abstract
This research establishes the relationship between the influence of the stability of 6 magnesium compounds on their cellular uptake and focuses on the comparation between them, finding out which is the magnesium compound with the best bioavailability, depending on the stability. Mg2+ was dosed from tissues taken from various mice organs after the administration of compounds containing it, during the shelf life of the compounds, respectively at 6/12 months after their expiration. Different quantities of substances were also used � 25/50/100/200/300 mg/day/mouse, in groups of 2 mice for each dose. The samples were administered by gavage, following in parallel the possible side effects that may occur. During the shelf life of the compounds and at 6 months after expiration, in all organs, the lowest value was obtained for magnesium oxide and the highest value was detected for magnesium citrate. At 12 months after expiration, in all organs, the lowest/highest value was obtained in the case of oxide/orotate, respectively. It was found that the highest concentration of magnesium is stored in the spleen and lowest in lungs. The data obtained demonstrated a good stability of the tested substances (indicated by maintaining the cellular uptake rate) even 6 months after the expiration date.
Highlights
Magnesium is a cation with predominant intracellular localization, only 1% of Mg2+ is found in the extracellular fluid, most of it being in the form of free ions and the rest being linked to plasma proteins [1]
Because this study has a special characteristic given by the small sample size, the best way to observe the data was to plot the mean value obtained from the experimental data, knowing that each organ has a different way to collect/store the magnesium compounds
The data obtained demonstrated a good stability of the tested substances, indicated by maintaining the cellular uptake rate, including the compounds being in 6 months after expiration date
Summary
Magnesium is a cation with predominant intracellular localization, only 1% of Mg2+ is found in the extracellular fluid, most of it being in the form of free ions and the rest being linked to plasma proteins [1]. Some of the main functions of magnesium in human biology include the preservation of ionic gradients (keeping intracellular sodium and calcium low and potassium high), cellular and tissue integrity, mitochondrial oxidative phosphorylation (ATP production and activation) and DNA, RNA and protein synthesis and integrity [2]. Mg2+, Ca2+ and K+ are correlated with each other They are relevant for the proper functioning of the whole organism and the modification of the serum level of Mg2+ determines the serum variations of other ions values [4].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
