Abstract
The kindling model of epileptogenesis is characterized by the induction of a persistent reduction of seizure threshold after repeated exposures of the brain to stimuli which were initially subconvulsive. We studied the ability of repeated injections of pentylenetetrazol (PTZ) to induce kindling. Subconvulsive doses of PTZ (20–25 mg/kg, i.p.) were administered to rats every 4 days for a total of 21 treatments. The convulsive response score of PTZ-treated rats remained elevated upon challenge with 22.5 mg/kg PTZ after a 3-week PTZ-free period. Studies on the mechanisms involved in PTZ-induced kindling revealed that hepatic microsomal P-450 concentrations were unchanged after chronic PTZ treatment. No significant changes in brain amino acids, including GABA and taurine, two neuroinhibitory amino acids which have been implicated in the regulation of seizure phenomena, were found in PTZ-kindled animals.
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