Abstract
Objectives: To give an overview of investigations that have increased our understanding of the pathogenesis of chronic generalized muscular pain and hyperalgesia [tender points] in the fibromyalgia syndrome [FS] and in chronic fatigue syndrome [CFS]. Results and Conclusions: The results of current research support the following hypothesis that includes both peripheral [muscular] and central factors. The changes in the central nociceptive system that leads to central sensitization of nociceptive neurons are probably the specific features of muscular pain in FS and CFS. The muscular changes indicating a localized disturbance of microcirculation, which can excite and sensitize nociceptors in the muscle, represent promoting or triggering factors and are not specific for fibromyalgia.
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