Aspects of the molecular pharmacology of GABA B receptors

Abstract

Receptor subtypes with pharmacological characteristics distinct from the classical GABA A receptor have emerged in recent years. Prominent among these is the GABA B receptor which, although membrane bound, is not associated with the chloride ion channel but instead influences the movement of potassium and calcium ions. Whilst no information is available from molecular biology studies, pharmacological analysis has indicated a clear separation from GABA A sites and the receptor has become firmly established in mammalian physiology. The purpose of this review is to illustrate aspects of GABA B pharmacology with consideration of the potential therapeutic application of receptor ligands.