ASPECTE PARTICULARE ALE BOLILOR DERMATOLOGICE LA PACIENŢII CU INFECŢIE HIV

Abstract

Objectives. To describe particular aspects of dermatoses in HIV-positive patients and assess clinical and therapeutical correlations. Material and methods. A systematic review was performed of the medical literature, totaling 49 works, to evaluate information on the following dermatological diseases: syphilis malignant, pruritic papular eruption of HIV, molluscum contagiosum, infection due to varicella-zoster virus or human papilloma virus, cutaneous histoplasmosis, Kaposi’s sarcoma, non-melanoma skin carcinomas, skin and soft tissue infections, HIV associated pruritus, HIV immune reconstruction syndrome (IRIS) associated dermatoses, vitiligo, lupus erythematosus, and Norwegian scabies. Results. Dermatological conditions are among the first clinical manifestations of AIDS, the number of patients with dermatitis being inversely proportional to the CD4 + count and proportionate to the stage of disease. Mucocutaneous manifestations associated with HIV-1 infection are classified into primary and secondary, but their pathogenesis is not completely elucidated, and secondary complications are associated with a lower HIV prevalence since HAART has become available. Conclusions. The majority of dermatological diseases in HIV positive patients have a clinically more severe course, with a prolonged evolution, are more resistant to treatment, tend to recur more frequently and may exacerbate during the first months of initiating HAART, due to immune reconstruction inflammatory syndrome.