Abstract
Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction.The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
Highlights
Restrained eaters (RE) are a group of individuals who constantly restrict their eating
Participantes Fueron incluidos 132 individuos de sexo femenino, no relacionados entre sí, sin antecedentes de patologías psiquiátricas ni consumo de fármacos psicotrópicos, con edades comprendidas entre 18-25 años
Van Den Eede F, Venken T, Del-Favero J, Norrback KF, Souery D, Nilsson LG, et al Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder
Summary
Restrained eaters (RE) are a group of individuals who constantly restrict their eating. La expresión reducida del gen y la función derivada de una variación importante en la región de control transcripcional de este (the serotonin.transporter-gene-linked polymorphic region; 5-HTTLPR), están ligadas a múltiples condiciones psicopatológicas, incluyendo las alimentarias[8,14,15]. El polimorfismo de 5-HTTLPR corresponde a una variante genética en la cual ocurre una inserción-deleción de un fragmento de 44 pares de bases (bp) en el gen SLC6A4, donde la variante más corta (deleción) (short/short o s/s) resulta en menor actividad transcripcional y mayor vulnerabilidad a trastornos afectivos[16,17,18]. En el contexto conceptual antes descrito, proponemos desarrollar un programa de investigación que evalúe el rol general y la asociación particular, de los polimorfismos de 5-HTTLPR y CRF-BPs11 con la restricción alimentaria crónica. Se explora si la presencia de los polimorfismos de 5-HTTLPR y CRF-BPs11 se asocia con la condición de DC
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