Abstract
There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. However systematic reviews of the existing evidence have shown that such association varies across populations with different genetic ancestry.To evaluate the association of IL-1B-511 and IL-1RN polymorphism and Helicobacter pylori IgG antibodies CagA, with gastric cancer in two Colombian cities located in a high risk area for gastric cancer.A case-control study including 46 gastric cancer cases and 99 controls with non-atrophic gastritis from a high risk zone for gastric cancer. Polymorphism genotyping was carried out by polymerase chain reaction (PCR) and IgG CagA status by ELISA.IgG CagA seropositive individuals had an increased gastric cancer risk (odds ratio (OR) = 11.56; 95% confidence intervals (CI) 2.62-50.91 in Tunja and OR = 19.66, 95%CI 0.98-395 in Bogotá). IL-1B-511TT carriers in Tunja had increased risk of gastric cancer (OR = 11.31; 95%CI 1.20-106.54)), while IL-1RN*2 alelle carriers in Bogotá showed an inverse association with gastric cancer risk (OR = 0.03; 95%CI 0.01-0.65).This study adds evidence to the positive association of Helicobacter pylori CagA positive strains with non-cardial gastric cancer etiology. There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area.
Highlights
There is an association of interleukin (IL)1B polymorphism with gastric cancer risk
Entre los pacientes de Tunja, portadores del genotipo IL-1B-511TT tuvieron un incremento en el riesgo cáncer gástrico (OR = 11,31; IC 95% 1,20-106,54) (Tabla 3)
Sicinschi LA, López-Carrillo L, Camargo MC, Correa P, Sierra RA, Henry RR, et al Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes
Summary
There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. Aim: To evaluate the association of IL-1B-511 and IL-1RN polymorphism and Helicobacter pylori IgG antibodies CagA, with gastric cancer in two Colombian cities located in a high risk area for gastric cancer. Conclusions: This study adds evidence to the positive association of Helicobacter pylori CagA positive strains with non-cardial gastric cancer etiology. Estas tasas colocan a Colombia entre los países con más alto riesgo para cáncer gástrico en el mundo[1]. Tunja (2.800 msnm) y Bogotá (2.600 msnm), ciudades localizadas en las montañas de los Andes, son claramente identificadas como de riesgo alto para cáncer gástrico[16 ]. El objetivo de este estudio es evaluar la asociación de los polimorfismos IL-1B-511 e IL-1RN y los anticuerpos IgG antiCagA de H. pylori con cáncer gástrico en esta zona de riesgo alto
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
