Abstract
Current standard management for intraductal papilloma (IDP) diagnosed at biopsy indicates complete surgical resection, but there are increasing controversies over whether and when routine excision is indeed necessary. The purpose of this study ( https://doi.org/10.1245/s10434-021-10188-7 ) was to determine the carcinoma upgrade rate and identify the associated predictive factors for IDP diagnosed at biopsy by meta-analysis. We searched the PubMed and EMBASE database for studies published from 2009 to 2020 that investigated the upgrade rate and predictive factors of IDP diagnosed at biopsy. A total of 7016 IDP cases diagnosed at biopsy and histologically examined after surgical excision were pooled from 44 original studies. Patients with benign IDP exhibiting one or more predictive factors might benefit from surgical excision, whereas patients with asymptomatic benign IDP without these predictive factors can be managed by imaging surveillance.
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