Abstract
Global communication by the epithelial cell layer is maintained through gap junctional complexes, separated from adjacent tissues by a basal lamina. Mesenchymal cells are loosely organized in a three-dimensional extracellular matrix, comprising connective tissue adjacent to the stroma. Conversion of epithelial cells to mesenhymal cells involves profound phenotypic changes, including loss of cell-cell adhesion, loss of cell polarity, and the acquisition of migratory and invasive properties (1).
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