Abstract
Background We tested the hypothesis that the Asian cystic fibrosis (CF) phenotype is comparable to the commonest genetic form of CF found in 50% of the white UK CF population using the UK CF Database, a national disease-specific patient registry. Methods 50 Asian CF patients were matched by Centre with 143 white homozygous ΔF508 patients for gender, age and chronic Pseudomonas aeruginosa status (a marker of morbidity). The authors compared FEV 1 and FVC% predicted, mean height, weight and BMI Z scores. Results FVC% predicted, weight and BMI Z scores were significantly worse in the Asians. Asian male/female FVC% predicted ( p-value, 95% CI) −15.1 ( p=0.001, −24.0, −8.8)/−15.2 ( p=0.014, −27.1, −3.3) compared with white controls. Asian females also had significantly worse FEV 1% predicted compared with controls (−14.9, p=0.025, 95% CI: −27.8, −2.0). Asians had significantly lower raw Z scores for weight (males p=0.002, females p=0.013) and BMI (males p=0.002, females p=0.008). Conclusions These data suggest that the Asian CF phenotype is as severe as the white controls with the homozygous ΔF508 phenotype but is worse in some outcomes, especially in Asian females. Socio-cultural factors and rare CF genotypes may contribute to the severity of CF in this vulnerable group.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.