Abstract
Brief Reports1 November 1977Aseptic Necrosis of Bone in MyxedemaHERBERT M. RUBINSTEIN, M.D., F.A.C.P., MARION H. BROOKS, M.D., F.A.C.P.HERBERT M. RUBINSTEIN, M.D., F.A.C.P.Search for more papers by this author, MARION H. BROOKS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-580 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGrowth retardation and delayed skeletal maturation are well-known manifestations of cretinism and juvenile myxedema. Patients with these conditions have abnormal ossification of epiphyseal centers that may appear porous, stippled, or fragmented on roentgenogram (epiphyseal dysgenesis). These changes are most pronounced in large ossification centers such as the femoral head and tarsal navicular. In the femoral head, clinical and radiographic features resemble Legg-Calvé-Perthes disease, but there are marked differences in pathology and response to thyroid hormone administration (1, 2). In the adult, thyroid hormone deficiency is associated with decreased metabolic activity and remodeling of bone (2), but overt skeletal disease has...
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