Aseptic meningitis complicating immunoglobulin therapy in AIDP

Abstract

Abstract Introduction A case of aseptic meningitis due to intravenous immunoglobulin is being reported. Aim To learn rare side effect of intravenous immunoglobulin. Case report Intravenous immunoglobulin is a safe therapy in many diseases. Side effects due to IVIG therapy usually are mild. Rarely can it lead to meningitis. We encountered aseptic meningitis in patient with acute inflammatory demyelinating polyneuropathy following IVIG. Results and discussion The incidence of drug-induced aseptic meningitis (DIAM) is unknown. Other drugs that have been associated with DIAM include NSAIDs, ranitidine, carbamazepine, vaccines against hepatitis B and mumps, immunoglobulin, and radiographic agents. Most of the reported cases had ITP as the primary disease or received high dose IVIG therapy. It has rarely been reported in patient with AIDP. Conclusions Recognition of aseptic meningitis as an adverse reaction following IVIG therapy is important as it may be treated effectively.