Abstract
Ascorbic acid at a concentration of 0.5 m M potently stimulated insulin and avian pancreatic polypeptide (APP) release from perifused chicken pancreas microfragments. Ascorbic acid stimulation of insulin release was accompanied by a selective toxic effect; stimulation of insulin release was not repeatable with a second ascorbic acid exposure although secretory responsiveness to theophylline remained. This effect may be involved in the diabetogenic action of ascorbic acid in several mammalian species and, as demonstrated herein, in the chicken. In the chicken in vivo chronic ascorbate treatment produced an abolition of glucose-stimulated insulin secretion as well as glucose intolerance. Release of APP occurred in response to repeated exposures to ascorbic acid. Dehydroascorbic acid did not mimic either the stimulatory effect or the selective toxic effect of ascorbic acid.
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