Abstract
Summary Synthetic ascorbic acid injected intravenously into human subjects having a deficiency of ascorbic acid in the serum did not result in an in vitro increase in the bactericidal action of whole blood for coagulase-negative staphylococci. Under similar circumstances, the intravenous administration of ascorbic acid was not followed by a rise in the bactericidal titer of serum for E. coli and E. typhosa. The bactericidal action of normal, human serum is not decreased for E. coli, E. typhosa and Shigella paradysenteriae Flexner when the ascorbic acid is completely oxidized in the presence of small amounts of copper.
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