Abstract
Arrested BALB/c 3T3 cells were induced to the G0-G1 transition by fetal calf serum (FCS) and S phase entry was measured by [3H]thymidine incorporation as an index of DNA synthesis. [3H]Thymidine uptake was proportional to FCS concentration. Ascorbate (ASC) itself was unable to increase DNA synthesis in these cells but potentiated it in the presence of both 1% and 10% FCS. [3H]Thymidine uptake profile was similar with and without ASC, and showing at 24 h an ASC stimulation of 69% in the presence of 1% FCS and 58% with 10% FCS. These data are discussed in reference to the participation of ASC on plasma membrane energization for membrane translocations and transport.
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