Abstract
SummaryAt the 2018 ASCO Annual Meeting, data from several interesting studies in HER2-positive metastatic breast cancer were presented. While not immediately practice changing, these trials indicate the future directions of drug development in this field. Early phase studies with novel antibody-drug conjugates (ADCs) such as trastuzumab-deruxtecan and trastuzumab-duocarmazine suggest relevant clinical activity of these drugs in pretreated patients; in addition, these ADCs may offer activity in low HER2-expressing tumours as well. ZW25, a bispecific HER2-directed antibody targeting the extracellular domains 2 and 4, showed excellent tolerability and considerable single-agent activity. A combination of T‑DM1 with the tyrosine-kinase inhibitor neratinib yielded high response rates, while a study of trastuzumab plus durvalumab reported disappointing results. Although formally negative, overall survival data from the PHEREXA trial suggest clinical activity of dual HER2-inhibition with trastuzumab and pertuzumab in patients with prior trastuzumab treatment for advanced disease. A combined analysis of two tucatinib studies showed that systemic therapy is active when continued in case of isolated central nervous system progression and stable extracranial disease after local therapy of brain metastases; finally, a small prospective observation in asymptomatic patients with reduced left ventricular ejection fraction suggests that anti-HER2 treatment may be reasonably safe in this population.
Highlights
None of the studies presented at this year’s American Society of Clinical Oncology (ASCO) Annual Meeting in the field of HER2-positive metastatic breast cancer (MBC) are immediately practice changing, several interesting data that add valuable information to the overall picture were presented
Early phase clinical trials with novel agents such as innovative antibody-drug conjugates (ADCs) or bispecific antibodies indicate the future directions of drug development in HER2-positive MBC
DS-8201a was tested in a phase I dose-escalation trial with multiple expansion cohorts: HER2-positive, trastuzumab-DM1 (T-DM1) pretreated MBC patients; patients with HER2-positive gastric cancer; MBC patients with low HER2-expression (HER2 1+/2+, HER2/neu ISH negative); and a cohort of patients with other HER2-positive or HER2/neu mutated solid tumours
Summary
None of the studies presented at this year’s American Society of Clinical Oncology (ASCO) Annual Meeting in the field of HER2-positive metastatic breast cancer (MBC) are immediately practice changing, several interesting data that add valuable information to the overall picture were presented. Early phase clinical trials with novel agents such as innovative antibody-drug conjugates (ADCs) or bispecific antibodies indicate the future directions of drug development in HER2-positive MBC
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
