ASCIA‐P66: SUBCUTANEOUS IMMUNOGLOBULIN ADMINISTRATION SURVEY: SYRINGE DRIVER VERSUS RAPID PUSH

Abstract

Subcutaneous immunoglobulin (SCIg) became registered in New Zealand 2013 with the introduction of rapid push (RP) administration. Prior to this SCIg was delivered via syringe driver only. A survey was sent to SCIg patients to compare syringe driver (SD) to RP administration. Included were adult and paediatric patients on either SD delivery versus RP infusion methods. Surveys were sent to 48 patients with 56% response rate. Respondents were RP 70% and SD 30%. The majority had administered SCIg for 1 – 2 years (56%). The abdomen was the most used infusion site (80%) regardless of administration method. The smallest administered volume was 10mls in paediatric patients. The largest volumes per site were 40 ml via RP and 45 ml via SD. Administration via SD was generally greater than 60 minutes (71%). RP administration times ranged from 10 – 60 minutes compared to SD 71 % administering 60 – 90 minutes. More local reactions were noted in SD than RP although the small sample size must be acknowledged. The majority of infusion rates were < 2 ml/min (RP 66%, SD 86%). RP showed higher infusion rates with a max 6 ml/min as was expected. No increase in adverse events was noted with increasing infusion rates. Infusion methods did not differ greatly between SD and RP for infusion site choice. Maximum volumes administered were similar in both groups. A larger percentage of RP infusions were administered at faster rates and over a shorter time period of time compared to SD. Local and systemic reactions were reported more in SD. Rate of reactions did not appear to increase with increased infusion rates.