Abstract
The ascending spinal pathways mediating pressor and heart rate responses to somatic afferent stimulation and induced exercise were studied in pentobarbital- and alpha-chloralose-anesthetized dogs. Bilateral sciatic nerve stimulation and induced exercise, via lumbosacral ventral root stimulation, produced pressor and heart rate responses that were blocked by bilateral dorsolateral sulcus (DLS) lesions of the lumbar spinal cord (L1-L3). Baroreceptor-mediated bradycardia were attenuated by sciatic stimulation but not by induced exercise. This attenuation was blocked by combined dorsolateral funiculus (DLF) and DLS lesions. Induced exercise with vascular occlusion to the muscle augmented the pressor and heart rate responses to exercise. These responses were blocked by combined DLS and DLF lesions. Such lesions did not influence responses to bilateral carotid occlusion, indicating that descending autonomic pathways were intact. Therefore, ascending spinal pathways mediating somatocardiovascular reflexes in anesthetized dogs are located in the lateral funiculus, extending from the dorsal root entry zone to a position somewhat ventral to the dentate ligament.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of applied physiology (Bethesda, Md. : 1985)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
