Ascending pathways from the nucleus of the solitary tract to the subfornical organ in the rat

Abstract

Electrical stimulation of the nucleus of the solitary tract (NTS) produced orthodromic excitation ( n=28, 15%) and inhibition ( n=6, 4%) of the activity of neurons in the subfornical organ (SFO) in male rats under urethane anesthesia. Almost all ( n=26) of the excitatory responses ( n=28) were blocked by microiontophoretically applied phentolamine, an α-adrenergic antagonist, but not by timolol, a β-adrenergic antagonist. In contrast, the inhibitory response of all the neurons ( n=6) tested was not affected by either phentolamine or timolol. Approximately two-third ( n=19) of SFO neurons that demonstrated the excitatory response to NTS stimulation exhibited an increase in neuronal activity in response to hemorrhage (10 ml/kg b.w.t.). Hemorrhage did not cause any change in the activity of all the neurons that demonstrated the inhibitory response to NTS stimulation. These results suggest that the excitatory pathways from the NTS to the SFO may transmit the peripheral baroreceptor information through α-adrenoreceptor mechanisms.