Abstract
• Arzoxifene (LY353381) is a novel third-generation selective estrogen receptor modulator (SERM) that is a derivative of raloxifene. Like tamoxifen, arzoxifene has estrogen-agonistic properties that result in protection from bone loss and produces beneficial effects on serum lipids.1 Unlike tamoxifen, arzoxifene does not appear to result in endometrial hyperplasia, and in fact, has demonstrated efficacy in treating uterine carcinomas.2
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