Abstract
A novel class of 4-arylamino-phthalazin-1-yl-benzamides is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display potent VEGFR-2 inhibitory activity with an IC 50 as low as 0.078 μM in an HTRF enzymatic assay. These compounds are relatively selective against a small kinase panel.
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