Abstract

The influence of mefloquine and additional antimalarial drugs on ( 3H) adenosine uptake, macromolecular synthesis, and cell stability was determined in rodent red cells parasitized with Plasmodium berghei . High arylmethanol to cell ratios induced lysis, whereas inhibition of macromolecular synthesis occurred at lower drug/cell ratios. A 2-acetylpyridine thiosemicarbazone rapidly suppressed ( 3H) adenosine uptake, and also blocked macromolecular synthesis by parasitized cells.

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