Aryl Indolizines I: Synthesis Properties of Some Phenylindolizines

Abstract

Several aromatically substituted indolizines were prepared for possible psychotropic activity utilizing the Tschitschibabin method, and the susceptibility of the nucleophilic position toward benzoyl chloride was established. The properties of the prepared compounds indicated that those with an aromatic halide are not susceptible to nucleophilic attack such as the formation of alkoxy derivatives and also that those compounds containing the p-nitrophenyl group could be reduced to the corresponding amino compounds only under drastic conditions not normally expected of such compounds.