Abstract
The “anatomical” links between bone remodeling and bone circulation are evident: numerous arterial capillaries adjoin osteoclastic resorption lacunae and the areas of bone formation where osteoblasts proliferate are very often bordered by a venous sinus. All epidemiological studies agree that patients with arterial disease are frequently osteoporotic. Conversely, patients with low bone density have an increased risk of cardiovascular disease. This should encourage us to offer bone densitometry to “cardiovascular” patients and to screen for vascular disorders in our patients with osteoporosis. This association is certainly based on common risk factors: tobacco use, sedentary lifestyle and low estrogen levels, but other hypotheses are being confirmed: involvement of increased osteoprotegerin levels in osteoporosis and the formation of calcified vascular plaques, role of FGF23 and Klotho protein, and direct damage caused by intraosseous ischemia.
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