Artificial tissue creation under microgravity conditions: Considerations and future applications.

Abstract

Traditional tissue engineering methods often fail to promote robust cell growth and differentiation, limiting the development of functioning tissues. However, the microgravity conditions created by rotating wall vessel bioreactors minimize shear stress and unload the gravitational force usually placed on cells. In a microgravity environment, cell proliferation, cell differentiation, and the 3D organization of cells are altered, potentially encouraging the formation of more biosimilar artificial tissues for certain cell types. Additionally, cells in these engineered tissues display lowered immunogenicity, pointing to the transplantation potential of tissues engineered in microgravity conditions. However, these benefits are not consistent across all cell types, and the long-term impact of microgravity on tissue development and stability remains an unanswered question. Even so, there is potential that with further research, microgravity tissue engineering will have productive clinical applications for medical and pharmaceutical purposes.