Abstract
Replacement of the endocrine functions of pancreatic β cell presents a special challenge in substitute medicine to treat the major chronic non-communicable disease called diabetes mellitus in developing societies. A completely noninvasive diagnostic and therapeutic technique for diabetic patient can be possible with the help of bio medical equipments, so this completely implantable long term closed loop Insulin delivery systems are of great interest for biomedical therapy. With appropriate control algorithm, we can imitate behavior of mal functioning organs with highly specific, reliable, stable,&long-lasting glucose sensor paves the new way for long-term therapeutic system for diabetes.
Highlights
The term Artificial β Cell is used exclusively for systems, aimed at replacing the endocrine function of the β cell
This artificial β cell consists of a number systems, such as Sensing system Controlling system Insulin delivery system Power source system Radio telemetry system
The hard wear resistant, corrosion resistant biocompatible, inert nano crystalline Zirconia ceramic and silicon carbide can be used as a best materials for this purpose[5]. This idea of implanting miniaturised and encapsulated micro/nano electronic equipment paves a new era in substitute medicine
Summary
The term Artificial β Cell is used exclusively for systems, aimed at replacing the endocrine function of the β cell. The β cells, which occupy the central portion of the islet in Pancreas (Endocrine Part), comprise about 80% of its mass. They secrete insulin, a fuel-storing (anabolic) hormone that promotes sequestration of carbohydrate, Protein, & fat in storage depots in the liver, muscle and adipose tissue. The increase in blood glucose levels on account of insulin deficiency leads to a disease called diabetes mellitus, which is the most common endocrine disease in developing societies, affecting as many as 12–15% of people in India. WHO has predicted that the number of diabetic patient Increases from 84 million to 228 million by the year 2025. Depression is a common psychiatric disorder among diabetic patients.
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