Abstract
Cardiovascular surgery represents a field where the anesthetist frequently deals with quickly evolving conditions associated with anesthesia, perfusion, and the scope of surgery, that have a direct and indirect impact on the oxygen delivery to organs and tissues and its consumption ratio. The prospects of predicting the oxygen concentration influential factors on the brain create a possibility for effective decisions in the crucial moments of cardiac surgery during a cardiopulmonary bypass, to choose specific neuroprotection to decrease postoperative neurologic complication risk. Nowadays, near-infrared spectroscopy (NIRS) technology has been used to perform cerebral oximetry analysis. By reviewing available literature, the work on the possible dependence of artificial blood circulation on oxygen concentration in the brain is provided. This research aims to investigate how artificial circulation, specifically the flow and viscosity of the fluid equivalent to blood, affects oxygen concentration in the cerebral phantom. The thesis contains methodology for measuring the concentration of oxygen was considered, as well as the manufacture of a phantom of the brain and an equivalent blood fluid. The results illustrate that the artificial blood flow rate has a non-linear effect on the oxygen concentration in the brain phantom. This was confirmed through the value of the oxygen concentration in the brain phantom under conditions of artificial blood circulation rSO<sub>2avg</sub>.= 85% with laminar flow and the value of rSO<sub>2avg</sub>.= 78% with turbulent flow. Additionally, it was proven that as the viscosity of the blood-equivalent fluid increases, the oxygen concentration decreases almost linearly. The calculated average rSO<sub>2</sub> value at minimum viscosity η=2.0 mPa∙s and flow rate Q=0.5 l/min has maximum rSO<sub>2avg</sub>.=85%, while at maximum viscosity η=4.2 mPa∙s, rSO<sub>2</sub> average value was the smallest rSO<sub>2avg</sub>.=72%. The study demonstrates that the type and rate of flow, as well as viscosity of the cardiopulmonary bypass, affect the measurements of oxygen concentration in the brain phantom.
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