Abstract
Objective To study the influences of the strenuous running training program on the knee joint articular cartilage. Methods At the age of 16 weeks, 5 male Wistar rats started running on a horizontal treadmill. Thereafter, the rats were trained for 45 days continuously. The rats ran 1 km/day at the speed of 20 m/min. Five matched male rats served as controls. Knees of the rats were studied by whole-mounted section, Hematoxylin and Eosin (HE) stain, safranin O stain. Results The cartilage surfaces were intact after the running exercise. The glycosaminoglycan concentration was decreased by an average of 66% in the superficial zone, 56% on the middle zone, but no difference was found in the deep zone. The glycosaminoglycan concentration was increased by 38% in the calcified cartilage. Conclusion Strenuous running induced marked decrease of proteoglycan in the uncalcified cartilage, but induced no osteoarthritis in this rat strenuous running model. Key words: Knee; Articular cartilage; Running exercise; Glycosaminoglycan
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