Abstract
Brucella spp. are zoonotic intracellular pathogens that infect a variety of livestock species, causing devastating agricultural losses on a global scale and severe illness in humans. Working in the understudied ovine pathogen, B. ovis, Varesio et al. (e00808-20) report that strains defective in cysteine biosynthesis have diminished growth in complex medium, enhanced sensitivity to hydrogen peroxide in vitro, and enhanced susceptibility to host killing in the intracellular niche of human and ovine cells. Thus, cysteine anabolism plays an important role in oxidative stress physiology and infection biology of B. ovis.
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