Articles of Significant Interest in This Issue

Abstract

YggS is a member of the pyridoxal 5′-phosphate (PLP)-binding protein family (COG0325), which is conserved across domains and has been implicated in maintaining the homeostasis of B6 vitamers. Vu et al. (e00383-20) show that strains devoid of YggS accumulate PLP in the growth medium. By replacing the native pathway for de novo PLP synthesis in Salmonella enterica with a heterologous PLP synthase, they show an epistatic interaction between YggS and PdxH, the pyridoxine 5′-phosphate (PNP)/pyridoxamine 5′-phosphate (PMP) oxidase. Together, YggS and PdxH may modulate the cycling of PLP→PMP→PLP.