Abstract
Subacute sclerosing panencephalitis (SSPE), a fatal complication of measles, is caused by persistent measles virus (MeV) infection in the brain. Shirogane et al. (e00528-21) show that host proteins, the cell adhesion molecule 1 (CADM1) and CADM2, are involved in MeV spread in neurons. Remarkably, these molecules interact in cis with the MeV attachment protein on the same cell membrane, which in turn triggers the fusion protein-mediated membrane fusion. This novel molecular mechanism, receptor-mimicking cis-acting fusion triggering, enables MeV to spread transsynaptically between neurons, thereby causing SSPE.
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