Abstract
Metformin is one of the most heavily prescribed antidiabetes drugs globally, is passed by humans largely unchanged, and is one of the most prevalent anthropogenic compounds entering wastewater treatment plants. Biodegradation of metformin had been shown to produce guanylurea, which was previously considered to be a final “dead-end” product. Studies by Tassoulas et al. (e03003-20) demonstrated the complete pathway of guanylurea mineralization by a Pseudomonas mendocina isolate. The enzyme initiating biodegradation, guanylurea hydrolase, was purified and characterized. Guanylurea hydrolase was shown to be evolutionarily related to triuret hydrolase and biuret hydrolase and may have most recently evolved from the latter.
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