Abstract
Birkle and Brown (e00476-20) propose and review evidence for a novel mode of innate immunity whereby live, infected host cells induce phagocytes to phagocytose the infected cell, thereby potentially reducing infection. They discuss evidence that live host cells, infected by virus, bacteria, or other intracellular pathogens, release signals that recruit phagocytes to phagocytose the infected cell. Digestion of the infected cell within the phagocyte can curtail host infection but may also result in cross-presentation of pathogen antigens, resulting in innate and adaptive immunity.
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